Priority Research Paper Volume 14, Issue 10 pp 4195—4210
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Figure 2. The lower dose of 50 mg/kg CQ did not cause significant pathological changes in the liver and the heart. (upper panel): Pathological changes in the liver of controls (A) and treatment (50 mg/kg) (B–D) consisted of hydropic degeneration and hepatocyte necrosis. The changes were visible mostly in portal areas and as they became more advanced, they spread through the lobule. Fibrosis and mononuclear inflammatory infiltrates were also present on occasion in portal spaces. (lower panel): In the heart of controls (E) and treatment (50 mg/kg) (F–H), interstitial oedema, intercalate disks fragmentation, loss of myocardiocyte striations and even areal necrosis could be seen, more frequent and more intense with increasing treatment dosage. Abbreviation: Vc, central vein. N = 10 for each group.