Priority Research Paper Volume 14, Issue 10 pp 4195—4210
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Figure 7. Serum insulin growth factor binding protein 3 was decreased by the chloroquine treatment. Treatment for 2 months with increasing doses of CQ did not cause significant changes in the body weight (A). Note that serum IGFBP3 was significantly decreased in serum collected from animals treated with CQ for 3 months (B). There was no statistically significant difference in the levels of serum IGF-1 and IRS of treated animals (C, D). Data are mean ± SD values. N = 15 for each group.