Research Paper Volume 14, Issue 10 pp 4220—4246

Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence

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Figure 4. Exploratory factor analysis (EFA). (A) Scree plots for oncogene-induced senescence (OIS), paracrine senescence (Paracrine), HMF replicative senescence (HMF RS) and HDF replicative senescence (HDF RS) models. Red line indicates eigenvalue = 1. (B) Polar plot of factor loading values for factor 1 from OIS EFA model (designated Nuclear Size). 1–62 refer to features (Table 2). Blue shaded area indicates factor loading threshold of 0.5. (C) Factor loading diagram for OIS EFA model with factor designations. Equivalent diagrams for other senescence models are found in Supplementary Figure 3).