Research Paper Volume 14, Issue 12 pp 5075—5085
The minor allele of rs17427875 in long non-coding RNA-HOXA11-AS influences the prognosis of subarachnoid hemorrhage (SAH) via modulating miR-15a and STAT3 expression
Figure 4. Compared with the A allele located in HOXA11-AS, the T allele located in HOXA11-AS showed a stronger capability to suppress the expression of miR-15a (A) and enhance the expression of STAT3 mRNA (B) and protein (C), as well as HOXA11-AS (D) in THP-1 cells. Meanwhile, ELISA analysis indicated that P-HOXA11-AS-T exhibited a stronger capability to increase the expression of STAT3 (E), TNF-α (F) and NF-κB (G) in THP-1 cells (*P value < 0.05 vs. NC group; **P value < 0.05 vs. P-HOXA11-AS-A group).