Research Paper Volume 14, Issue 12 pp 4976—4989

Differential impact of glycemic control and comorbid conditions on the neurophysiology underlying task switching in older adults with type 2 diabetes


Figure 4. Neural and behavioral switch cost correlations. Significant correlations between neural and behavioral switch costs were apparent in the early high gamma left cerebellar peak ((A) r45 = 0.34, p = 0.020) and the late high gamma right parieto-occipital peak ((B) r45 = −0.35, p = 0.016). In the left cerebellum, greater neural switch costs were associated with greater behavioral switch costs, while in the right parieto-occipital lower neural switch costs were related to greater behavioral switch costs. This distinct pattern of neural responses leading to differential behavioral outcomes was further investigated, and this analysis showed group-specific recruitment of each region ((C) F1,43 = 5.52, p = 0.024), whereby those with comorbid conditions (shown in green) had greater switch costs in left cerebellum, while those without comorbidities (shown in blue) had greater switch costs in the right parieto-occipital region. *p < 0.05, **p < 0.01, ***p < 0.001.