Research Paper Volume 14, Issue 12 pp 5177—5194

LncRNA PEG11as silencing sponges miR-874-3p to alleviate cerebral ischemia stroke via regulating autophagy in vivo and in vitro


Figure 1. PEG11as expression in tMCAO/R mice and cellular OGD/R models. (A, B) TTC staining evaluation and statistical analysis of mouse cerebral infarct volume induced by MCAO 1 h/R 24 h (n = 6). (C) Volcano plot of lncRNA expression differences in ischemic penumbra. Red spots represent differentially expressed genes. (D, E) PEG11as level determined by RT-PCR in the ischemic penumbra of cerebral IS/R mice (n = 6) and OGD/R-treated N2a cells (n = 6). One-way ANOVA followed by the Tukey’s post-hoc-test was used, data are shown as mean ± SD. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. sham group.