Research Paper Volume 14, Issue 12 pp 5177—5194

LncRNA PEG11as silencing sponges miR-874-3p to alleviate cerebral ischemia stroke via regulating autophagy in vivo and in vitro


Figure 2. PEG11as silencing alleviates the acute injury of cerebral neurons induced by cerebral IS/R. (A) Illustration of the experimental procedure. (B) The average neurological scores of Clark and mNSS tests (n = 10). (C, D) Representative pictures and statistical chart for TTC staining. (E, F) Representative images and statistics of TUNEL staining of brain sections for assaying neuronal apoptosis. (G, H) Representative pictures and statistical chart of Nissl staining in the CA1 and CA3. n = 6. One-way ANOVA followed by the Tukey’s post-hoc-test was used, data are shown as mean ± SD. ***P < 0.001 vs. sham group, #P < 0.05 or ##P < 0.01 vs. IS/R+shRNA-NEG group. Abbreviation: ns: no statistically different vs. IS/R group.