Research Paper Volume 14, Issue 17 pp 6905—6916

NOX4 promotes Kupffer cell inflammatory response via ROS-NLRP3 to aggravate liver inflammatory injury in acute liver injury


Figure 7. NOX4-KO suppresses liver injury in mice. (A) H&E staining (n = 5). Mice in KO and WT groups did not exhibit any obvious tissue injury, with no bubble-like structure or inflammatory response. Mice in WT-D/L group exhibited distinct inflammatory injury and obvious cell injury, along with inflammatory response. While tissue injury in KO-D/L group was alleviated. (B) Histochemical staining of NLRP3 (n = 5). NLRP3 expression dramatically increased in WT-D/L group, higher than that in WT and KO groups, while NLRP3 expression in WT and KO groups was relatively low, and that in KO-D/L group decreased. (C, D) Detection of ALT and AST levels (n = 5). ALT and AST levels dramatically decreased in KO-D/L group, lower than those in WT-D/L group. *P < 0.05, compared with WT group; #P < 0.05, compared with KO group; P < 0.05, compared with WT-D/L group.