Research Paper Volume 14, Issue 18 pp 7364—7377
M1 macrophage-derived exosomes synergistically enhance the anti- bladder cancer effect of gemcitabine
Figure 3. Effect of M1-Exo-GEM on MB49 apoptosis. (A, B) Caspase-3 and Bax were negatively expressed in the Control group, while M1-Exo and GEM could enhance the Caspase-3 and Bax expressions, as manifested by significantly higher fluorescence intensity than that of Control. In the M1-Exo-GEM group, these expressions were further up-regulated, with higher fluorescence intensity than that of M1-Exo and GEM. (C) M1-Exo-GEM could be taken up by MB49 cells, which were PKH-67-positive.