Research Paper Volume 14, Issue 16 pp 6381—6414

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells


Figure 3. The selective MCL-1 inhibitor MIK665 augments the senolytic effects of non-selective BCL-2 inhibitors ABT-737 and ABT-263. The matrices show the selective senolytic area (blue), synergy area for senescent cells (orange), and the area with synergistic and senolytic effect (blue-orange) of tested compounds. The synergy and senolytic effect of the combination of MIK665 and ABT-737 (A) and MIK665 and ABT-263 (B) on different models of senescence are shown. IR-P – IR-induced senescence derived from proliferating cells; DIS – drug-induced senescence. The statistical analysis was carried out using the two-tailed Student's t-test; *, P > 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. At least three biological replicates were analyzed.