Research Paper Volume 14, Issue 16 pp 6381—6414

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells


Figure 4. The selective MCL-1 inhibitor S63845 augments the senolytic effects of selective BCL-2 (ABT-199) and BCL-XL (A1331852) inhibitors. The matrices show the selective senolytic area (blue), synergy area for senescent cells (orange), and the area with synergistic and senolytic effect (blue-orange) of tested compounds. The synergy and senolytic effect of the combination of ABT-199 and S63845 (A) and A1331852 and S63845 (B) on the model of IR-induced senescence derived from proliferating cells (IR-P). The statistical analysis was carried out using the two-tailed Student's t-test; *, P > 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. At least three biological replicates were analyzed.