Research Paper Volume 14, Issue 16 pp 6594—6604

Figure 3. MiR-375 mitigates cell proliferation and angiogenesis. (A) Expression of miR-375 was significantly increased after the treatment with miR-375 in RMECs. (B) Cell viability was decreased by treatment with miR-375. (C, D) miR-375 inhibited the incorporation of BrdU (C) and the protein levels of PCNA (D). (E, F) Cell migration (E) and tube formation (F) were repressed by miR-375 in RMECs. Scale bar: 100 μm (E) and 500 μm (F), respectively. All values are represented as the mean ± standard error of the mean. n = 3 per group. *P < 0.05.