Research Paper Volume 14, Issue 16 pp 6740—6755
Sulforaphane inhibits angiotensin II-induced cardiomyocyte apoptosis by acetylation modification of Nrf2
Figure 7. Diagram of the mechanism by which SFN prevents Ang II-induced cardiomyocyte apoptosis. Ang II activates oxidative stress by increasing ROS leading to inflammation, oxidative stress and fibrosis in cardiomyocytes. SFN prevent Ang II-induced cardiomyocyte apoptosis by inhibiting HDACs to activate Nrf2 and downstream antioxidant genes.