Research Paper Volume 14, Issue 17 pp 6936—6956

Clinical significance for diagnosis and prognosis of POP1 and its potential role in breast cancer: a comprehensive analysis based on multiple databases


Figure 11. The effect of POP1 on proliferation, migration, and apoptosis of BC cells. (A, B) The qRT-PCR results suggested that siRNAs could successfully knock down the expression of POP1 in MDA-MB-231 and MCF-7. (C, D) Compared with the si-NC group, POP1 deficiency significantly inhibited the proliferation of MDA-MB-231 and MCF-7. (EH) The depletion of POP1 significantly reduced the migration ability of MDA-MB-231 and MCF-7 cells, as demonstrated by transwell migration assays (magnification, 200×) and wound healing assays (magnification, 20×). (I) Cell apoptosis was detected via flow cytometry. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.