Research Paper Volume 14, Issue 17 pp 6936—6956

Clinical significance for diagnosis and prognosis of POP1 and its potential role in breast cancer: a comprehensive analysis based on multiple databases


Figure 4. Meta-analysis of multiple cohorts to verify the robustness of POP1. (A) Meta-analysis. The heterogeneity was < 50%, so the fixed effect model was used for analysis (SMD = 0.95, 95% CI: 0.78, 1,12). (B) Regardless of the exclusion of any cohort, the combined standardized mean difference (SMD) was greater than 0. (C) Sensitivity analysis and specificity analysis. (D) The summary receiver operating characteristic (SROC) curve demonstrated that the results are reliable. (E, F) Begg test and Egger test did not find significant publication bias. Abbreviations: SMD, Standardized mean difference; SROC, Summary receiver operating characteristic.