Integrated PPI- and WGCNA-retrieval of hub gene signatures for soft substrates inhibition of human fibroblasts proliferation and differentiation

Ziran Xu; Tian Zhou; Yin Wang; Leijie Zhu; Jihao Tu; Zhixiang Xu; Lisha Li; Yulin Li

doi:doi:10.18632/aging.204258

← Back

Research Paper Volume 14, Issue 17 pp 6957—6974

Integrated PPI- and WGCNA-retrieval of hub gene signatures for soft substrates inhibition of human fibroblasts proliferation and differentiation

Figure 5. PPI network analysis of DEGs. (A) The PPI network of 698 DEGs. (B) Cluster1 and cluster 2 sub-networks obtained after MCODE analysis of PPI network. (C) MCC sub-network obtained after CytoHubba analysis of PPI network. (D) The legend of networks. The round represents down-regulated DEGs, the square represents up-regulated DEGs, and the size of the node graph represents the degree for (A), which denotes the number of nodes connected to each node. The colors of the nodes indicate the size of log₂ (fold change). The higher and lower the expression is, the redder and bluer it is, respectively.