Research Paper Volume 14, Issue 17 pp 6993—7002

Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways


Figure 1. Phps decreased the accumulation of AST, ALT and up-regulated the levels of GSH and down-regulated the levels of MPO in mice; Phps reduced the number of cell necrosis and the condition of structure damage of WT mice. Haematoxylin and eosin staining of liver tissues. The mice were received Phps (40, 60, 80 mg/kg) prior 1 h APAP (500 mg/kg) injection. (A, B), the levels of AST and ALT. (C), the content of MPO in liver. (D), the levels of GSH in liver. (E) the liver sections by H&E staining (scale bars: 200 μm). All data are presented as mean ± SD (three independent experiments). #p < 0.05 and ##p < 0.01 vs. control group; *p < 0.05 and **p < 0.01 vs. APAP group.