Research Paper Volume 14, Issue 17 pp 6993—7002
Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways
Figure 3. Phps enhanced the expression of ATG7, ATG12, ATG5 and ATG3 in APAP-induced acute liver injury of mice. The mice were received Phps (40, 60, 80 mg/kg) prior 1h APAP (500 mg/kg) injection and liver was collected for Western blot. (A), the expression of ATG7, ATG12, ATG5 and ATG3 in liver of mice. (B–E), Relative expression levels of all protein of all proteins including ATG7, ATG12, ATG5 and ATG3. All data are presented as mean ± SD (three independent experiments). #p < 0.05 and ##p < 0.01 vs. control group; *p < 0.05 and **p < 0.01 vs. APAP group.