Research Paper Volume 14, Issue 17 pp 6993—7002

Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways


Figure 4. Phps could not inhibit AST, ALT elevations and alleviate GSH consumption; Phps could not improve histopathological changes in Nrf2-/- mice. The mice were received Phps (80 mg/kg) prior 1 h APAP (500 mg/kg) injection (A, B), the levels of AST and ALT. (C), the levels of GSH in liver. (D) the liver sections by H&E staining (scale bars: 200 μm). All data are presented as mean ± SD (three independent experiments). #p < 0.05 and ##p < 0.01 vs. control group; *p < 0.05 and **p < 0.01 vs. APAP group.