**Figure 3.** **Volcano plot of plasma miRNAs associated with trajectory of MMSE scores.** The MMSE rate change (x axis) is the equivalent of the regression coefficient of the interaction term in the linear mixed model. These beta estimates, pooled from ten imputed datasets, are from linear mixed models adjusted for age, education, alcohol consumption, smoking status, and follow up time. The 33 extracellular miRNAs that interacted with follow up time significant at FDR *q*-value < 0.05 are labelled. MiRNAs with positive and negative interaction terms are plotted in red and blue, respectively. Abbreviations: FDR: False Discovery Rate; MMSE: Mini-Mental State Examination; n.s.: not significant.