Research Paper Volume 14, Issue 17 pp 6859—6886

Extracellular microRNA and cognitive function in a prospective cohort of older men: The Veterans Affairs Normative Aging Study


Figure 3. Volcano plot of plasma miRNAs associated with trajectory of MMSE scores. The MMSE rate change (x axis) is the equivalent of the regression coefficient of the interaction term in the linear mixed model. These beta estimates, pooled from ten imputed datasets, are from linear mixed models adjusted for age, education, alcohol consumption, smoking status, and follow up time. The 33 extracellular miRNAs that interacted with follow up time significant at FDR q-value < 0.05 are labelled. MiRNAs with positive and negative interaction terms are plotted in red and blue, respectively. Abbreviations: FDR: False Discovery Rate; MMSE: Mini-Mental State Examination; n.s.: not significant.