Research Paper Volume 14, Issue 17 pp 7109—7125

Realgar (As4S4), a traditional Chinese medicine, induces acute promyelocytic leukemia cell death via the Bcl-2/Bax/Cyt-C/AIF signaling pathway in vitro

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Figure 2. Morphological changes in NB4 cells after exposure to different concentrations of realgar for 24 h. The cells were treated with different concentrations of realgar for 24 h, and typical images were captured by a light field microscope. (A) Control cells; (B) cells exposed to 12.5 μg/ml of realgar; (C) cells exposed to 25.0 μg/ml of realgar; (D) cells exposed to 50.0 μg/ml of realgar; and (E) cells exposed to 75.0 μg/ml of realgar. Inset, magnified cells.