Research Paper Volume 14, Issue 17 pp 7109—7125

Realgar (As4S4), a traditional Chinese medicine, induces acute promyelocytic leukemia cell death via the Bcl-2/Bax/Cyt-C/AIF signaling pathway in vitro


Figure 5. Effect of different concentrations of realgar on ATP generation in APL cells for 24 h. The cells were treated with different concentrations of realgar (0, 12.5, 25.0, 50.0 and 75.0 μg/ml) for 24 h. Then, the ATP levels were measured using a commercial ATP assay kit according to the manufacturer's instructions. Data were obtained from three independent experiments and are presented as the mean ± SD. **P < 0.01 and ***P < 0.001.