Research Paper Volume 14, Issue 18 pp 7300—7327

Age-related metabolic and neurodegenerative changes in SAMP8 mice


Figure 6. Decreased total number of neurons in the cortex and hippocampus of SAMP8 immunohistochemically stained for NeuN: representative photomicrographs of the brains of SAMR1 (AC) and SAMP8 (DF) mice. Black-framed inserts in right down corners show a magnified area of hippocampus, and (G, H) the quantification. Total number of stained particles was counted in cortex, percentage of the stained area expressed as a % of a respective control group was used in hippocampus. Data are mean ± SEM, analyzed by 2-way ANOVA with Bonferroni post test. Significance is *P < 0.05 and **P < 0.01. * SAMP8 compared to SAMR1,+ age-dependent changes in SAMR1, and # age-dependent changes in SAMP8. n = 4-5 mice per group, 8-10 sections per brain.