Research Paper Volume 14, Issue 18 pp 7300—7327

Age-related metabolic and neurodegenerative changes in SAMP8 mice


Figure 7. Decreased neurogenesis in the hippocampi of SAMP8 mice immunohistochemically stained for doublecortin (DCX): representative photomicrographs of the brains of SAMR1 (AC) and SAMP8 (DF) mice, (G) a detail of DCX-stained neurons in the subgranular zone of the hippocampus, and (H) the quantification. Data are mean ± SEM, analyzed by 2-way ANOVA with Bonferroni post test. Significance is ***P < 0.001. * SAMP8 compared to SAMR1, + age-dependent changes in SAMR1, and # age-dependent changes in SAMP8. n = 4-5 mice per group, 8-10 sections per brain.