Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer


Figure 1. MiRNAs reversed ADR-resistance in MCF-7/ADR cells. (A) Expression of miR-326, miR-328, miR-451 and miR-155 in MCF-7 and MCF-7/ADR cells were detected by Real-time RT-PCR. ***P < 0.001, comparing with MCF-7 cells. (B) MCF-7/ADR cells and MCF-7/ADR cells transfected with miRNAs were treated with ADR (43 μM) for 48 h. Cell viability was measured by CCK-8 assay. All data represent the means ± SD of three independent experiments. **P < 0.01, ***P < 0.001, comparing with non-transfection group.