Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer


Figure 2. MiRNAs regulated the expression of MRP1, BCRP, MDR1 genes. The expression levels of MRP1, BCRP and MDR1 in MCF-7/ADR cells and MCF-7/ADR cells transfected with miRNAs were detected by Real-time RT-PCR. All data represent the means ± SD of three independent experiments. **P < 0.01, ***P < 0.001, comparing with control group.