Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer


Figure 3. MiRNAs regulated the expression of MRP1, BCRP and P-gp proteins. (A) Western blot was conducted to detect the expression of MRP1, BCRP, P-gp and β-actin in MCF-7/ADR cells and MCF-7/ADR cells transfected with miRNAs. (B) Quantitative analysis of the results in (A). All data represent the means ± SD of three independent experiments. *P < 0.05, ***P < 0.001, comparing with control group.