Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer


Figure 6. GQ and miR-451 enhanced the inhibitory effect of ADR on tumor growth in mice. Tumor-bearing mice were treated with ADR (3 mg/kg) or the complex of miR-451 (0.55 mg/kg) and liposome CDO14 (1.5 mg/kg) via tail vein injection, or treated with GQ (18 mg/kg) by gavage for 6 times at an interval of 3 days. (A) Tumors removed from the mice after treatment. (B) Volume of tumor in mice during the treatment. (C) Body weight of mice during the treatment. All data represent the means ± SD, n=3. *P < 0.05, **P < 0.01, ***P < 0.001, comparing with control group.