Research Paper Volume 14, Issue 17 pp 7170—7185

A circadian rhythm-related gene signature for predicting relapse risk and immunotherapeutic effect in prostate adenocarcinoma


Figure 5. Functional enrichment analysis for CR-related gene signature. (A) Enriched biological processes included cytoplasmic translation, oxidative phosphorylation, mitochondrial respiratory chain complex assembly. (B) Enriched cell components included mitochondrial protein-containing complex, ribosome, inner mitochondrial membrane protein complex. (C) Enriched molecular functions included structural constituent of ribosome, oxidoreduction-driven active transmembrane transporter activity and electron transfer activity. (D) Enriched KEGG pathways included ribosome, diabetic cardiomyopathy, chemical carcinogenesis (E, F) Gene set enrichment analysis (GSEA) showed the top 10 KEGG signaling pathway including AMPK signaling pathway, dopaminergic synapse, central carbon metabolism in cancer, NF-kappa B signaling pathway and others.