Research Paper Volume 15, Issue 24 pp 15640—15656

Protective effect of fluoxetine against oxidative stress induced by renal ischemia-reperfusion injury via the regulation of miR-450b-5p/Nrf2 axis


Figure 1. Fluoxetine prevented renal IRI injury in male rats. Fluoxetine prevented renal IRI in male rats. (A) Diagram of the renal IRI animal model. (B) Survival curves for SHAM, FLX, IRI and IRI+FLX groups. (C) Serum creatinine (Scr) and blood urea nitrogen (BUN) of blood sample collected at 24 h reperfusion from SHAM group, FLX group, IRI group, and IRI+FLX group. (D) H&E staining of renal tissues in SHAM, FLX, IRI, and IRI treated with Fluoxetine rats at 3 and 21 days after operation (magnification ×400). (E) Masson staining was used to evaluate renal injury and fibrosis. Mean seminiferous tubular diameter (magnification ×400). Data were presented as Mean ± SD, *significant difference vs. SHAM group (P < 0.05); #significant difference vs. IRI group (P < 0.05).