Research Paper Volume 14, Issue 18 pp 7455—7469

Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway


Figure 1. Low-intensity focused ultrasound (LIFUS) relieves tissue damage, neuronal degeneration and necrosis. (A) Schematic diagram of the relationship between ultrasonic path and rat brain anatomy. The inset shows a vertically incident ultrasonic beam. (B) A representative magnetic resonance imaging image of a rat brain. (C) LIFUS in rats. (D) Representative hematoxylin and eosin staining images of three groups of cortical tissues showing areas of necrosis, Scale=50 um. (E) Representative Nissl staining of three groups of cortical tissues demonstrates necrotic degeneration of neurons, Scale=50 um.