Research Paper Volume 14, Issue 18 pp 7505—7516

ZCCHC12 promotes the progression of osteosarcoma via PI3K/AKT pathway


Figure 3. ZCCHC12 facilitated cell migration and inhibition of it induced cell apoptosis and S-phase arrest in OS cells. (AD), migration ability of cells was detected by Transwell migration assays (A and B) and wound-healing assays (C and D). (EH), the quantifications of cell migration were presented by the column chart. (I) Flow cytometry images of the cell apoptosis and (J) column bar graph of apoptotic cells. (K) Cell cycle in HOS cells with ZCCHC12 knockdown and (L) percentages of cells in each cell cycle phase are shown in the bar graph. scale bar: 200 μm. n = 5; *P < 0.05, **P < 0.01, ***P < 0.001.