Research Paper Volume 14, Issue 18 pp 7527—7546

Ubiquitin-like protein FAT10 promotes renal fibrosis by stabilizing USP7 to prolong CHK1-mediated G2/M arrest in renal tubular epithelial cells


Figure 6. FAT10 was up-regulated and positively correlated with renal fibrosis in patients with calculi related chronic kidney disease. (A) Representative photos of renal sections from normal kidney and biopsy samples from patients with calculi related chronic kidney disease. IHC, immunohistochemistry; scale bar = 50 μm. (B) The expression of renal FAT10 at initial biopsy positively correlated with the tubular interstitial fibrosis index in a partial correlation analysis. (CF) Scatter plots show a positive correlation between FAT10 and USP7, CHK1, CDKN1A, TGF-β, respectively. (GI) The statistical analysis data show that the expression level of USP7 was positively correlated with the expression level of CHK1, CDKN1A and TGF-β. *P < 0.05, **P < 0.01.