Research Paper Volume 14, Issue 18 pp 7527—7546

Ubiquitin-like protein FAT10 promotes renal fibrosis by stabilizing USP7 to prolong CHK1-mediated G2/M arrest in renal tubular epithelial cells


Figure 7. Model summarizing the role of FAT10 in renal fibrosis response to UUO injury. Upon UUO injury, FAT10 up-regulation stabilizes USP7 expression, thereby leading to CHK1-mediated G2/M arrest in RTECs, which further drives fibrogenic responses.