**Figure 6.** **Gompertz–Makeham mortality and survival analysis demonstrates decreased early mortality with compensating increased aging rate in Sen and OKSM interventions.** Survival data for each intervention are shown together with the best-fit survival curve on the right and the corresponding mortality trajectories are shown on the left. Initial log(Mortality) parameter (**A**) can be read as the intersection between mortality curve and y-axis at age zero. The slope of the mortality curve is proportional to 1/MRDT. The dashed purple line illustrates hypothetical mortality trajectory assuming additivity of effects elicited by OKSM and Sen. (**A**, **B**) Mortality trajectories and survival curve for cohorts with continuous induction of OKSM, Sen or OKSM+Sen and controls. (**C**, **D**) Mortality trajectories and survival curve for cohorts with induction of OKSM, Sen or OKSM+Sen for 24 h every three days and matched controls. (**E**, **F**) Mortality trajectories and survival curve for cohorts with induction of OKSM, Sen or OKSM+Sen for 12 h every three days and matched controls. Note that flies subject to continuous induction (Panels **A** and **B**) are permanently kept at 25°C and are therefore aging more rapidly than flies cultured at 18°C and induced for only for short periods. The slope of the mortality trajectory of controls in A is therefore approximately two times as larger, compared to that of controls in panels **C** and **E**. For exact MRDT and A parameter values and associated confidence intervals see: (