Research Paper Volume 15, Issue 2 pp 308—352

Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice


Figure 10. Body weight effects on femoral cortical parameters. The effect of body weight (BW) on femoral cortical parameters in two different age groups, 18 mo and 22 mo mice. BW effect was observed in Co.Th and Co.Area in 18 mo CTRL/HBW mice and BV/TV, BMD, Pe.Cir in 22 mo VWR/HBW mice. (A) bone volume fraction (BV/TV), (B) bone mineral density (BMD), (C) cortical thickness (Co.Th), (D) cortical area (Co.Area), (E) periosteal circumference (Pe.Cir), and (F) endosteal circumference (En.Cir), were measured by microCT. *: p < 0.05, and **: p < 0.01, HBW vs. LBW mice. Abbreviations: CTRL: control group; VWR: voluntary wheel running group; CBW: Combined groups; LBW: Low body weight group (18 mo: n = 8 CTRL, n = 10 VWR; 22 mo: n = 4 CTRL, n = 4 VWR); HBW: High body weight group (18 mo: n = 8 CTRL, n = 7 VWR; 22 mo: n = 4 CTRL, n = 4 VWR).