Research Paper Volume 14, Issue 23 pp 9617—9631
A circadian rhythm-related biomarker for predicting prognosis and immunotherapy efficacy in lung adenocarcinoma
Figure 1. Construction of a novel gene signature. (A) CR levels were significantly upregulated in the para-cancerous samples compared to the tumor samples. (B) CR levels could distinguish tumor patients with normal patients, with area under curve (AUC) of 0.895. (C) 1224 differentially expressed genes (DEGs) were obtained between the paracancerous and tumor groups. (D) 12 eligible CR-related genes were acquired by intersecting 1224 DEGs, 4237 prognostically relevant genes and 7302 CR-related genes. (E, F) 12 eligible CR-genes were further screened using LASSO regression analysis.