Research Paper Volume 14, Issue 23 pp 9466—9483
Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation
Figure 2. FDA-approved drugs decrease mammosphere formation. The effects of two FDA-approved drugs, carvedilol and ciprofloxacin, are shown. (A) Note that carvedilol is effective in inhibiting CSC propagation, at a concentration of 25 μM, its IC50, and 50 μM completely inhibits mammosphere formation. (B) Ciprofloxacin significantly decreases mammosphere number, at the concentrations of 100 μM, its IC50. Bar graphs are shown as the mean ± SEM; t-test, two-tailed test. ***p < 0.001, ****p < 0.0001. Chemical formulae are indicated.