Research Paper Volume 15, Issue 1 pp 230—245
Increased expression of GPX4 promotes the tumorigenesis of thyroid cancer by inhibiting ferroptosis and predicts poor clinical outcomes
Figure 1. Differential mRNA expression profiles in thyroid cancer patients stratified by GPX4 level. (A) Comparison of GPX4 expression between different types of cancers and adjacent tissues based on TCGA. ns indicates p≥0.05, *p<0.05, **p<0.01, ***p<0.001. GPX4 expression is higher in thyroid cancer tissue than in adjacent normal tissue according to TCGA (B) as well as GSE27155 (C) and GSE33630 (D) from GEO. Differentially expressed mRNAs between the two groups are displayed by volcano plots (E) and heatmaps (F).