Editorial Volume 15, Issue 2 pp 290—292

Figure 1. Increased MHCII expression by DCMo during aging. (A) Classical monocyte subsets arise from GMPs and MDPs, which contribute to classical monocyte heterogeneity. Neutrophil-like monocytes (NeuMo) are GMP-derived, whereas DC-like monocytes (DCMo), which give rise to moDC, are MDP-derived. The origins of other classical monocyte subsets have not yet been defined. (B) During aging, DCMo expression of MHCII genes increases, MHCII proteins become detectable at the cell surface, and MDPs/DCMo produce proportionally more moDC.