Research Paper Volume 15, Issue 4 pp 932—946
Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice
Figure 2. Effects of AMPKα isoform reduction on recognition memory in aged mice. (A) Novel object recognition (NOR) experiments demonstrated that long-term recognition memory was impaired with aging in Cre+/- and AMPKα2 cKO mice. In contrast, aged AMPKα1 cKO mice showed normal recognition of novel objects over familiar objects. n=8 for Cre+/- and AMPKα1 cKO, n=10 for AMPKα2 cKO. **p<0.01. Unpaired two-tailed t-test. (B) Time spent with the novel object during the NOR test. n=8 for Cre+/- and AMPKα1 cKO, n=10 for AMPKα2 cKO. *p<0.05. One-way ANOVA and Tukey’s test. (C) NOR discrimination index [(time spent exploring novel object − time spent exploring familiar object) / total exploration time]. n=8 for Cre+/- and AMPKα1 cKO, n=10 for AMPKα2 cKO. *p<0.05. One-way ANOVA and Tukey’s test.