Research Paper Volume 15, Issue 4 pp 932—946

Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice


Figure 4. Effects of AMPKα isoform reduction on hippocampal long-term synaptic plasticity in aged mice. (A) Hippocampal late LTP (L-LTP) induced by two-train high-frequency stimulation (HFS, denoted by the arrows). (B) Representative fEPSP traces before and 90 minutes after HFS. (C) Cumulative data showing quantification of mean fEPSP slopes 90 min after delivery of HFS. n=13 for Cre+/- and AMPKα2 cKO, n=10 for AMPKα1 cKO. p=0.23, One-way ANOVA.