Editorial Volume 15, Issue 7 pp 2362—2363

Figure 1. Newly developed closed-loop system and correlative electro- and force myograph (CLEF) analysis. (A) A closed-loop system to measure the bite force and EMG, simultaneously. The video data, EMG data, and bite force data were stored on a personal computer (PC) with Bonsai software. The bite force values were processed online in Bonsai; when the bite force values exceeded the threshold value, the PC output a signal to reward the mouse with water. (B) First, we created a scatter plot showing the correlation between EMG muscle activity and bite force when a mouse chewed a bite force sensor. A non-linear regression curve was created from the scatter plot. Then, the bite force during the mouse chewing sunflower seeds was estimated from EMG muscle activity based on the regression curve. For more details, see text and Kuramoto et al., 2022 [5].