Research Paper Volume 15, Issue 5 pp 1652—1667
ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis
Figure 7. Schematic diagram summarizes the mechanisms by which ANGPTL2 facilitates lymphangiogenesis in human lung cancer cells. ANGPTL2 increases VEGF-A production and subsequently facilitates LEC lymphangiogenesis in human lung cancer cells via the integrin α5β1 receptor, p38 and NF-κB signaling.