Editorial Volume 15, Issue 7 pp 2364—2366

Figure 1. Aging results in structural deteriorations and functional decline of the heart. One central mechanism of aging is cell senescence and several studies have provided evidence that clearing senescent cells with senolytics in male rodents ameliorate cardiac decline and dysfunction with aging and in aged mice with ischemic cardiomyopathy. That senescence is central to cardiac aging in female sex remains unaddressed. Nevertheless, we demonstrated for the first time that senescence clearance by senolytics improves cardiac remodeling and function after myocardial infarction in very old female mice [7].