Research Paper Volume 15, Issue 6 pp 1977—2004
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice
Figure 1. Hsp22 overexpression preconditioning improved LPS induced learning and memory impairment in mice. (A) Flowchart figure of animal experiment. (B) Representative diagram of Morris water maze of mice in each group. Hsp22 overexpression preconditioning reduces escape latency in mouse MWM test (C) and Hsp22 overexpression pretreatment increases the number of mice crossing the platform (D). (***p < 0.005, ***p < 0.005 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; #p < 0.05, ##p < 0.01 vs. LPS+Lv-Hsp22-NC).