Research Paper Volume 15, Issue 6 pp 1977—2004
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice
Figure 2. Effect of Hsp22 on LPS-induced activation of NLRP3/Caspase-1/IL-1β pathways in the mice hippocampus tissue. The serum levels of IL-6, TNF-α and IL-1β. (A–C) (**p < 0.01, ***p < 0.005, ***p < 0.005 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; ##p < 0.01, ##p < 0.01, #p < 0.05 vs. LPS). The protein band of NLRP3, Caspase-1, IL-1β and its expression in the mice Hippocampus tissue (D–F). (**p < 0.01, *p < 0.05, **p < 0.01 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; #p < 0.05, ###p < 0.005, #p < 0.05 vs. LPS+Lv-Hsp22-NC).