Research Paper Volume 15, Issue 6 pp 1977—2004
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice
Figure 3. Hsp22 overexpression pretreatment improves hippocampus tissue damage induced by LPS. (A) Histological analysis of Hippocampus tissue via HE staining (×200). (B) The degeneration rate of neurons in LPS group was higher than that in control group, and the difference was statistically significant (***p < 0.005). The degeneration rate of neurons in LPS+Lv-Hsp22 group was lower than that in LPS+Lv-Hsp22-NC group, and the difference was statistically significant (###p < 0.005). (C) Histological analysis of Hippocampus tissue via Nissl Staining (×200).