Research Paper Volume 15, Issue 6 pp 2115—2135

Pan-cancer analysis reveals the associations between MMP13 high expression and carcinogenesis and its value as a serum diagnostic marker

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Figure 6. Pathway analysis and PPI network construction for MMP13 in different tumors. (A) The potential effect of upregulation of MMP13 on oncogenic pathway activity was analyzed in pan-cancer. The number in each cell represents the number of cancer types associated with the specific pathway. (B) The association between MMP13-based GSVA score and activity of cancer-related pathways in pan-cancers. *P-value <= 0.05; #FDR <= 0.05. (C) PPI network analysis of interacting genes with MMP13 by GeneMANIA webtool. (D) Functional enrichment analysis of MMP13-related genes in PPI network. (E) Western blotting was used to evaluate the expression of MMP13 and EMT molecular markers in 7 paired human LUAD tissues and adjacent normal tissues. N and T represented cancer tissue and adjacent normal tissue, respectively.