Research Paper Volume 15, Issue 6 pp 2136—2157

Figure 5. CDKN2A predicts the immunotherapy response of cancer patients. (A) spearman correlation thermogram shows the correlation between CDKN2A expression in pan-cancer and immune regulatory factors. Red and blue represent positive correlation and negative correlation, respectively. (B) The correlation between CDKN2A expression and tumor mutation in cancer. (C) Correlation between CDKN2A expression and microsatellite instability in pan cancer. (D, E) Kaplan-Meier curve (anti-PD-L1, urology) of patients with low CDKN2A and high CDKN2A in IMvigor210 cohort; proportion of urological tumor patients in subgroups of low CDKN2A and high CDKN2A in imvigor210 cohort which responded to PD-1 treatment. (F, G) Kaplan-Meier curves (anti-PD-L1, melanoma) of patients with low and high CDKN2A in GSE91061-melanoma; proportion of melanoma patients who responded to PD-1 treatment in subgroups of low and high CDKN2A in GSE91061-melanoma. The asterisk symbolizes the statistical p value (*p<0.05, ** p<0.01, *** p<0.001).